Early access: First LightWeigh units are available to early-access partners
LightWeigh: characterize your nanoparticles in minutes
A compact, label-free instrument that measures the concentration, size and mass of your 20 – 300nm particles at single-particle level — AAV, LV, LNP, EV and more.
Half a day
of training
Compact:
45x60cm
Patented
As simple as load, press, read
Pipette 10µL of your sample, press start, and read your results — no labelling, no calibration, and no settings to change between particle types. A measurement takes 3 – 10 minutes, and training takes less than half a day.
Empty/full capsid ratio
Quantify the empty, partial and full capsid ratio of your viral and non-viral vectors — and the concentration of each population — at single-particle level. A critical quality attribute for gene therapy, measured in minutes on 10 µL.
Yield control
Get an absolute particle concentration to track and optimize your production yield, label-free and standard-free — robust across dilutions from 1×10⁸ to 1×10¹⁰ particles/mL
Aggregation control
Detect aggregates and distinct sub-populations early in your process — across viral vectors, LNPs and extracellular vesicles — that bulk methods average out.
Validated across particle types
Our instrument is agnostic to the type of nanoparticles. It works with any type of biological 20-300nm nanoparticles and also on other non-biological nanoparticles such as gold nanoparticles (down to 10nm) and silica nanoparticles.
AAV — empty/full capsid discrimination and concentration
Lentivirus — separation of distinct sub-populations in production samples
Adenovirus — discrimination of particle populations
LNPs & Liposomes — detection of loading via mass shift vs empty control
Extracellular vesicles — size and mass profiling of highly heterogeneous samples
Phages — full vs empty discrimination
Gold nanoparticles — size and mass profiling of heterogeneous samples
LightWeigh specifications
Pipette 10 µL of your sample, press start, and read your results — no labelling, no calibration, and no settings to change between particle types. A measurement takes 3 – 10 minutes, and training takes less than half a day.
Particle concentration range
10⁸ – 10¹⁰ particles / mL
Minimum sample volume required
10µL
Sensitivity (for biological objects)
20nm – 300nm
Mass measurement accuracy
<3%
Labelling required
No
Calibration required
No
Works in usual buffers
Yes
Measurement time
3 – 10min (resp. concentration – size & mass)
Training required
< half a day
Ability to be GMP compliant
Yes
See it on your own samples
Characterize your own samples — yield, empty vs full, aggregation — in minutes: