Early access: First LightWeigh units are available to early-access partners
LightWeigh: characterize your nanoparticles in minutes
A compact, label-free instrument that measures the concentration, size and mass of your 20 – 300nm particles at single-particle level — AAV, LV, LNP, EV and more.
half a day
of training
Compact:
45x60cm
Patented
As simple as load, press, read
Pipette 10µL of your sample, press start, and read your results — no labelling, no calibration, and no settings to change between particle types. A measurement takes 3 – 10 minutes, and training takes less than half a day.
Empty/full capsid ratio
Quantify the empty and full capsid ratio of your viral and non-viral vectors — and the concentration of each population — at single-particle level thanks to mass mass measurement. A critical quality attribute for gene therapy, measured in minutes on 10 µL.
Yield control
Get an absolute particle concentration to track and optimize your production yield, label-free and standard-free — robust across dilutions from 1×10⁸ to 1×10¹⁰ particles/mL
Aggregation control
Detect aggregates and distinct sub-populations early in your process — across viral vectors, LNPs and extracellular vesicles — that bulk methods average out thanks to size and mass measurements at single-particle level.
Validated across particle types
Our instrument is agnostic to the type of nanoparticles. It works with any type of biological 20-300nm nanoparticles and also on other non-biological nanoparticles (e.g., gold and silica nanoparticles)
AAV
Discrimination between full and empty AAV capsids thanks to the mass
Lentivirus
Separation of distinct sub-populations in production samples thanks to mass and size
Adenovirus
Separation of distinct sub-populations in production samples thanks to mass and size
Detection of loading via mass shift vs empty control
Size and mass profiling of highly heterogeneous samples
Full vs empty discrimination and ability to assess step-by-step the impact of a purification process
Gold nanoparticles
Size and mass profiling of heterogeneous samples. For gold nanoparticles, sensitivity down to 10 nm.
LightWeigh specifications
Particle concentration range
10⁸ – 10¹⁰ particles / mL
Minimum sample volume required
10µL
Sensitivity (for biological objects)
20nm – 300nm
Measurement time
3 – 10min (resp. concentration – size & mass)
Mass measurement accuracy
<3%
Labelling required
No
Calibration required
No
Works in usual buffers
Yes
Training required
< half a day
Ability to be GMP compliant
Yes
See it on your own samples
Characterize your own samples — yield, empty vs full, aggregation — in minutes: